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Of the 100 patients initially enrolled in the study, 11 were classified as dropouts due to being lost to follow-up, while 4 patients discontinued treatmentone due to hypoglycemia, one due to lack of efficacy, and two due to challenges in accessing the medicationresulting in 85 patients completing therapy until the studys conclusion

Moreover, the strong effects observed in animal studies have not always translated to humans (Forssten et al., 2022

J BioMed Nanotechnol

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Microdosing is a proactive approach to potentially maintain health or support longevity goals, while macrodosing is a therapeutic approach to correct a more advanced metabolic imbalance

Second, Mn metabolism cannot be studied in isolation because of its shared transport and signaling pathways with other transition metals