doi: 10.3389/fbioe.2025.1729166 Received 21 October 2025 Revised 01 December 2025 Accepted 17 December 2025 Published 15 January 2026 Volume 13 - 2025 Edited by Ling Wang, Dalian Medical University, China Reviewed by Nicola Alessio, University of Campania Luigi Vanvitelli, Italy Yesuf Adem Siraj, Bahir Dar University, Ethiopia Updates Copyright 2026 Hu, Li, Hu, Shan, Tang, Jiang, Yi, Chen, Jin, Wang and Wang
Reported concerns include local injection reactions, potential immunogenicity from copper exposure with chronic use, and theoretical risks if peptides activate unintended growth pathways
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reactions persisting beyond 48 hours or involving induration suggest sensitivity to the bacteriostatic water preservative (benzyl alcohol) rather than the peptide itself
Source: Stabler, S
Cagrilintide incorporates targeted amino acid substitutions and structural modifications that enhance resistance to enzymatic breakdown and extend receptor signaling activity during biochemical and cellular assays