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3.1.2 EVs mediate cytochrome P450 enzyme synthesis and affect hormone levels Hyperandrogenism is closely associated with cytochromeP450(CYP450), particularly evident in the pathophysiology of PCOS (Zhai et al., 2023)

It is speculated that SARS-CoV-2 infection could exacerbate this mechanism by depleting Treg cells or diminishing their function due to suppression of FoxP3 ( 2.2 Autoreactive T cell activation and infiltration in the pancreas Beyond the failures of central and peripheral tolerance, the progression of T1D relies on the precise mechanisms by which autoreactive T cells are presented with self-antigens in the periphery