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The trade-off is a very short half-life of approximately 20-30 minutes after subcutaneous injection, making it unsuitable for systemic use and largely studied in local tissue applications [10]

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We stated that limiting the lookback period to no more than 12 months prior to posting the MRF would be consistent with section 2718(e) of the Public Health Service Act that refers to for each year, and our regulations that require the MRF to be updated at least annually ( 180.50(e) and 180.60(e))

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