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N Engl J Med [internet] 379(23):22372245
Because tirzepatide produces more weight loss than semaglutide (dual receptor versus single receptor), and because orforglipron is a single GLP-1 receptor agonist, there was an expected gap in potency
Once treatment stops, appetite and weight typically rebound in many cases, most or all weight is regained within a year
Activity of the mitochondrial calcium uniporter varies greatly between tissues
This has made the peptide relevant to studies of energy balance, nutrient response, and metabolic adaptation
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