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People with a history of severe gastrointestinal issues, such as gastroparesis (delayed stomach emptying), should avoid this medication, as it can exacerbate these conditions

Adv Immunol 65:111138 Bannwarth B, Labat L, Moride Y, Schaeverbeke T (1994) Methotrexate in rheumatoid arthritis: an update

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Whilst there is no established causal link between GLP-1 receptor agonists and acquired hypothyroidism, weight loss itself can sometimes unmask underlying thyroid conditions

However, pretreatment with 10 g/g GHK-Cu significantly increased both SOD activity and GSH levels, bringing them to values comparable to control mice

Mills KF, Yoshida S, Stein LR, et al. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metab. 2016;24(6):795-806. doi:10.1016/j.cmet.2016.09.013