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When retatrutide binds to GLP-1 receptors, it stimulates insulin release from the pancreas, reduces glucagon secretion, delays gastric emptying, and suppresses appetite through direct signaling to the brain

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This objectively quantifies changes in visceral fat, subcutaneous fat, and lean mass, allowing researchers to evaluate whether the combination is producing the hypothesized benefits (preferential visceral fat loss with muscle preservation)

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