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Modified structure designed to reduce binding to IGF-binding proteins (IGFBPs) in vitro

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Insulin-dependent glycogen synthesis is mediated via the activation of of glycogen synthase (GS)

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It has been discussed before, thatdue to the differential influence of enzymes and competing reactions in complex cellular systems 4,57 the midpoint redox potential of GRXs determined in vitro does not necessarily allow predictions on their redox states in vivo