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In mammalian reproduction, mTOR guides follicular recruitment, influences oocyte maturation in meiosis, coordinates signaling to granulosa/theca units, orchestrates puberty onset and influences ovarian aging [17, 20]
For water-soluble metabolites with diverse physicochemical properties, the lack of universal ISs remains a major bottleneck, as individual ISs are often required for each metabolite class, leading to high costs and limited feasibility
The AAFP has stated that berberine for weight loss lacks rigorous evidence, has potential harms. Thats not a condemnation of berberine across the board, its a specific and warranted caution about overstating its weight loss effects
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