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Body-weight scaling is not straightforward: allometric differences in metabolism between a 2 kg rodent model and a 40 kg dog mean a simple g/kg extrapolation may not translate

Both approaches yield roughly 20-24% weight loss in their respective optimal protocols

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Betz WJ (1970)

The gradual decline of testosterone with aging is parallel to the age-related fall in growth hormone secretion levels, resulting in lower circulating levels of insulin-like growth factor-I