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Shaking creates foam, introduces air bubbles, and causes physical stress that degrades the peptide through a process called denaturation

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This discussion compares tripeptides, exemplified by the well-studied GHK, with larger peptides such as the cyclic heptapeptide CyRL-QN15, the human cathelicidin-derived antimicrobial peptide LL-37, and the peptide Andersonin W-1 (AW1), containing 7, 37, and 72 amino acids, respectively [25, 67, 68]

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