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doi: 10.1016/j.tice.2022.102000, 44

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Results do not stop when injections stop

NOX1,4 and 5 are expressed in smooth muscle cells and NOX2 and 4 are expressed in cardiomyocytes, fibroblasts, or endothelial cells

Norea, A

[1] Bi-Amino Injections clinical rationale draws on pharmacokinetic evidence that intravenous arginine produces a sharp plasma peak followed by biphasic clearance, whereas citrulline bypasses splanchnic arginase activity, undergoes efficient renal conversion back to arginine, and sustains substrate availability for nitric-oxide synthase several hours beyond the initial infusion