BBB is a biological and physical barrier consisting of astrocytes, pericytes, and brain microvascular endothelial cells (BMECs) that maintains the dynamic between the peripheral circulation and the central nervous system (21)
5), and by inference, neurotoxic damage.53 Forgione and colleagues had previously hypothesized that GPX1 deficiency directly induces an increase in vascular oxidative stress, with attendant endothelial dysfunction.54 Glutathione peroxidases, particularly GPx1 have also been implicated in the development and prevention of many common and complex diseases, including cancer and cardiovascular disease (Fig
10.1038/s41375-018-0375-7 3
Douglass, J
Human organic anion transporter 1B1 (OATP1B1/OATP-C) and 1B3 (OATP1B3/OATP-8) function as bidirectional carriers and do not mediate GSH-bile acid co-transport
The rest is made from the amino acid methionine, which is converted to cysteine, the most important component of GSH