At a pre-symptomatic stage, the deletion of Trkb in iSPNs leads to the upregulation of Gsto2 , increasing DA levels by controlling AA homeostasis and impacting energy metabolism, leading to progressive motor dysfunctions
Systemic effects are rare in user reports but are not well characterized in published trials
Some individuals with inherited deficiencies of specific enzymes that synthesise glutathione may develop neurological complications later in life 22
Avoiding toxins like alcohol and processed foods that deplete glutathione
While glutathione can help detoxify the body from aldehydes, this task impairs its overall efficiency in other parts of the body
Dopamine Release and Uptake Classically, dopaminergic neurons release dopamine when an action potential reaches the axon terminal, inducing dopamine-containing vesicles to fuse with the cell membrane and release dopamine via exocytosis (Liu and Kaeser, 2019)