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Here is how many participants in each group hit specific milestones: 10% or more body weight loss: More participants achieved this with tirzepatide 15% or more body weight loss: Substantially more with tirzepatide 20% or more body weight loss: Significantly more with tirzepatide 25% or more body weight loss: 31.6% of tirzepatide users versus only 16.1% of semaglutide users Nearly twice as many people on tirzepatide achieved 25% or greater body weight loss compared to semaglutide

Side effects remain one of the primary drivers of discontinuation

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These distinctions were central to its development as a targeted metabolic peptide and continue to inform its use as a pharmacological reference in fat-metabolism research today

GLP-1 medications are not recommended during pregnancy or breastfeeding

Supplementary Figure 2 The original data of the western blotting