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NNMT transfers a methyl group from SAM onto nicotinamide, producing 1-methylnicotinamide while consuming methyl donors and contributing to NAD depletion

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Ethics approval The research was approved by the University of Kufas institutional ethics board (8241/2021) and the Najaf Health Directorate-Training and Human Development Center (Document No.18378/ 2021)

Low-concentration paclitaxel (36 nM) is reported to interfere with glutaminolysis, a process that is essential for ferroptosis