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Under chemotherapeutic stress, cancer cells can actively initiate the dialogue by releasing alarmins such as S100A8 to educate and activate CAFs, which in turn construct a reciprocal protective barrier [98]

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However, the side effects of cyclophosphamide can be severe and include nausea, vomiting, infertility, and hair loss

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The current review focuses on Se transport to the brain, primarily including selenoprotein P/low-density lipoprotein receptor-related protein 8 (LRP8, also known as apolipoprotein E receptor-2) dependent pathway, and supplementary transport routes of Se into the brain via low molecular weight Se-species