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Some users report decreased hunger and spontaneous reduction in caloric intake , although the long-term efficacy of this effect requires further research

Modification of HDL by lipid dicarbonyls such as isolevuglandins and MDA reduce its ability to drive cholesterol efflux from macrophages and protect against inflammatory stimuli such as LPS (283,285)

79 The selective depletion of these high-function states argues against a uniform decline and supports a pseudo-hierarchical erosion model, in which aging preferentially erodes the most potent functional tier, shifting the pool composition toward primed and committed states

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