Sobczak M, Saaga M, Storr MA, Fichna J (2014) Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives
Earlier GHRPs (like GHRP-2 or GHRP-6) triggered massive spikes in cortisol (stress hormone) and prolactin, leading to unwanted side effects like water retention and lethargy
This synthetic peptide is derived from a protein found in the stomach, and it works throughout the body to repair tissues, improve gut health, and reduce inflammation
Gong, L
Specifically, IRPs binding to IREs at the 5-UTR suppress translation of ferritin, FPN1, and amyloid precursor protein (APP), while IRP binding at the 3-UTR stabilizes mRNAs of TfR1 and DMT1, thereby promoting iron uptake under conditions of deficiency (Mai et al., 2023)
"Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes"