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If drinking is genuinely important to you, bring it to your prescriber, not to a DIY dose skip

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However, these gastrointestinal effects also contribute to the medication's side effect profile, which patients and healthcare professionals must carefully consider and manage

[123] The rate of dose reduction may depend on the duration of therapy, with more gradual tapering required for patients who have received prolonged treatment

most figures refer to pEC 50 values, i.e