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Two explanations for this discrepancy are worthy of consideration

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Using GO and Reactome enrichment analysis we also observed that the control group was defined by pathways related to mesenchymal cell proliferation and blood vessel formation, whereas the combination group was enriched in pathways related to metallothioneins and response to metal ions (Figure S7B-C)

doi: 10.1038/s41586-022-04985-7 6 BangS