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Secondly, TREM2 can restore microglia homeostasis through TREM2-APOE-mediated pathway, and realize the synergistic effect of TREM2 and its ligand APOE by regulating the main transcription factors homologous to microglia (including TGF-), thus increasing TREM2-mediated phagocytosis (Wei et al., 2024)

Souliotis VL, Vlachogiannis NI, Pappa M, Argyriou A, Ntouros PA, Sfikakis PP (2019) DNA damage response and oxidative stress in systemic autoimmunity

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Understanding why fatigue occurs, how long it typically persists, and practical management strategies can help patients navigate this common side effect whilst continuing beneficial therapy for type 2 diabetes or weight management

doi:10.1021/bi052483v