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( A ) Uniform manifold approximation and projection (UMAP) plot showing clustering of intestinal epithelial cell types isolated from the crypts of WT mice and analyzed by single-cell RNA sequencing

When the microneedle patch loaded with nano-drugs is applied to the skin, it first breaks through the stratum corneum barrier through physical puncture, rapidly dissolves and releases the encapsulated nanoparticles in the dermis [177]

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They have posited that " GHSs increase body fat by GH-independent mechanisms that may include increased feeding