switch to tirzepatide from semaglutide Why You Might Tolerate One Weight Loss Drug Better Than Another Switching from tirzepatide to semaglutide:

Research suggests that patients who spend 3-6 months slowly stepping down their semaglutide dose while simultaneously building exercise habits and refining meal patterns experience significantly less rebound than those who stop abruptly

Available online: 47.Gotfredsen C.F., Mlck A.M., Thorup I., Nyborg N.C., Salanti Z., Knudsen L.B., Larsen M.O

Laboratory evaluation typically shows elevated TSH, low free thyroxine (fT4), and increased TPOAb titers, while thyroid ultrasound reveals diffuse hypoechogenicity and heterogeneous parenchymal texture

One possibility is that the difference in efficiency in weight loss is due to a higher uptake of liraglutide in the CNS

Nature 380:435439 Henry TD, Annex BH, McKendall GR, Azrin MA, Lopez JJ, Giordano FJ, Shah PK, Willerson JT, Benza RL, Berman DS et al (2003) The VIVA trial: vascular endothelial growth factor in ischemia for vascular angiogenesis

Not an outlier group