First characterized in research by Goldspinks group, it is widely used in mechano-transduction and muscle biology studies
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The clinical rationale for obesity treatment extends beyond cosmetic benefit to meaningful cardiovascular risk reduction: Wegovy's label now includes cardiovascular risk reduction in overweight adults, fundamentally altering the value proposition for payers [1]
Liraglutide shares 97% sequence homology with human GLP-1 and can bind to and activate GLP-1R.78 The elimination half-life of liraglutide is 13 h, and only one injection per day is required.62 Lixisenatide Lixisenatide was developed by Sanofi to treat T2DM.64,93 Structurally, lixisenatide is based on the exenatide structure but lacks proline at position 38, and six lysines are linked after serine at position 39.94 The six lysine residues increase the rigidity of the molecules structure, thus allowing its drug properties to be improved.78 These changes stabilize its structure, prevent protein degradation of the molecule in the circulation, and increase the circulation time enough to ensure once-daily injection (compared with exenatide, which is injected two or three times daily)
*Correspondence: Panicos Shangaris [email protected] This article was submitted to Stem Cell Research, a section of the journal Frontiers in Cell and Developmental Biology These authors share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
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