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Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, Yamada M, et al

Several studies have reported that autophagy prevents RGC death in glaucoma animal models such as optic nerve transection and IOP elevation 24,25

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ROS include, superoxide anion radical (O 2 ), peroxy radical (ROO ), hydrogen peroxide (H 2 O 2 ), singlet oxygen ( 1 O 2 ), perhydroxyl radical (HO 2 ) and extremely reactive OH, Table 1

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Potential areas of expansion include: Cardiovascular outcomes: A dedicated CVOT, if not already required as a post-marketing commitment, would evaluate whether orforglipron reduces MACE in patients with established cardiovascular disease or high cardiovascular risk, following the precedent set by the SELECT trial for semaglutide