Xu G, Kaneto H, Lopez-Avalos MD, Weir GC, and Bonner-Weir S
High-Yield Points Rosuvastatin most commonly causes myalgia Important rare toxicities: myopathy and rhabdomyolysis Liver enzyme elevation may occur Symptomatic patients may need CK/LFT assessment and dose adjustment or discontinuation
& Van Tongeren, J
In a randomized, double-blind, breast cancer prevention trial (NSABP P-1 trial), alopecia (5.2% vs 4.4%) and skin adverse events (5.6% vs 4.7%) were reported more often in women at high risk for developing breast cancer who received 5 years of tamoxifen therapy (n = 6492) compared with placebo (n = 6484)
Over 75% of health plans and over 50% of employers are moderately or very concerned about off-label use of GLP-1s approved for type 2 diabetes, but awareness of how much current spend is off-label is notably lower: nearly half of employers and a quarter of health plans are unsure
Pregnancy & fertility considerations Ozempic is NOT recommended during pregnancy and should be discontinued at least two months before trying to conceive