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In contrast, cAMP signaling in response to GLP-1 was comparable between wild-type and mutant receptors, supporting the hypothesis that altered signaling with PF-06882961 was not due to a marked alteration of surface expression for the mutated constructs (Fig

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106 Selective activation of LXR in macrophages, without affecting hepatocytes, suggests the potential for targeting LXR in macrophage-mediated liver regeneration

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