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In an embryofetal development study in pregnant cynomolgus monkeys, subcutaneous doses of 0.015, 0.075, and 0.15 mg/kg twice weekly (0.4-, 2-, and 6-fold the MRHD) were administered throughout organogenesis, from Gestation Day 16 to 50

It strengthens interaction with the GATOR2 complex to indirectly reduce mTORC1 activity, and blocks amino acid-induced RagA/B GTPase activation to suppress mTORC1s lysosomal translocation [21]

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FIGURE 5 Recommendation: NAC could be considered for patients with NCF bronchiectasis who experience 2 exacerbations per year