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A consultation with a specialist can provide a deeper understanding of the root cause, whether its related to genetics, nutrition, or a medical condition

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Especially, AMPK is a potent inhibitor of the mTOR-mediated signaling, e.g., it can inhibit the MDSC-induced immunosuppressive responses, probably inhibiting the mTOR-STAT3 pathway [64]

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Beneficial and detrimental bacteria affect the development of RE by regulating inflammatory signaling pathways such as NF-B and JAK/STAT3, and through their metabolites such as bile acids and short-chain fatty acids