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For instance, extended use of high-dose iron chelators can induce iron deficiency in the body, adversely impacting hematopoietic function, while overdosing on certain antioxidant-based inhibitors may impair coagulation function ( Figure 7 )

Mitonuclear communication in homeostasis and stress

The manufacturer Eli Lilly (the same company behind the weight loss injection Mounjaro) expects orforglipron to be approved and available by early 2026

These changes are particularly relevant for people with insulin resistance or early type 2 diabetes

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