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Journal of toxicology

Introduction: GLP-1 receptor agonists Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) represent a major advancement in the pharmacological treatment of type 2 diabetes and obesity [1]

Nature 581 , 310315 (2020)

Phase 3 trials showed weight loss of up to 11.2% at the highest dose over 72 weeks

[0005] The prior art also describes a synthesis method using Fmoc solid phase sequential one by one coupling, wherein Mmt, Mtt, Dde, or ivDde protecting group is selected for temporary orthogonal protection when an amino acid is coupled to the side chain of the lysine, and then a certain method is selected for removing the protecting groups, allowing to couple on the side chain in sequence

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