Gretch 1, HALT-C Trial Group 1Department of Laboratory Medicine, University of Washington, Seattle, WA 2Division of Gastroenterology, University of California - Irvine, Irvine, CA, and Gastroenterology Service, VA Long Beach Healthcare System, Long Beach, CA 3Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 4New England Research Institutes, Watertown, MA 5Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, VA 6Section of Hepatology, Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Denver, CO 7Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, CA 8Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 9Departments of Medicine and Molecular & Structural Biology and the Liver-Biliary-Pancreatic Center, University of Connecticut Health Center, Farmington, CT 10Division of Gastroenterology and Hepatology, St

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Two distinct domains are recognized in each GST monomer: a N-terminal thioredoxin-like domain and a C-terminal alpha-helical domain
Cellular iron uptake, trafficking and metabolism: key molecules and mechanisms and their roles in disease
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Initiate the dosing regimen for each patient individually, taking into account the patients underlying cause and severity of pain, prior analgesic treatment and response, and risk factors for addiction, abuse, and misuse (see WARNINGS)