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Results of the GO enrichment and KEGG analysis of these target genes suggested that they are mainly involved in the regulation of inflammatory response, apoptotic process, regulation of cell proliferation, neutrophil extracellular trap formation, arachidonic acid metabolism, phospholipase D, HIF-1, and VEGF signalling pathways

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Genetic Predispositions in Detoxification and Glutathione Metabolism Variations in genes encoding glutathione S-transferases (GSTs), glutathione peroxidases (GPXs), and other antioxidant enzymes influence individual glutathione demand and responsiveness

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su respuesta descrita es no lineal (forma de U) respecto a dosis y tiempo (PMID 6145137), un patrn distinto al de agentes con relacin dosis-efecto ms directa

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