anhedonia glp-1 Receptor Agonists in Mood Disorders: A Psychiatric Perspective TheCut just released an article

Tirzepatide titration may continue as follows: Week 8: 7.5 mg weekly (if 5 mg was well-tolerated) Week 12: 10 mg weekly (for patients who need additional appetite suppression) Week 16: Up to 12.5 mg or 15 mg (maximum doses, used selectively) Ipamorelin adjustments: If well-tolerated at 200 mcg, may increase to 250 to 300 mcg daily Some physicians add a second daily dose (morning, fasted) for enhanced GH support If water retention or joint stiffness develops, dose may be reduced Labs at the 8-week mark should include IGF-1, thorough metabolic panel, HbA1c, and lipids

Oct 2022;46(10):1825-1832

doi: 10.1016/j.jff.2021.104812 175

At the N-terminus, the His7 of Semaglutide forms a direct hydrogen bond with the side chain of Gln234 and a water mediated hydrogen bond with Tyr241 of the receptor

Exercise-related hypoglycemia in diabetes mellitus

For the reconstitution math common to every peptide, see the main peptide calculator