PMID: 11 KraftVANBezjianCTPfeifferSRingelstetterLMllerCZandkarimiFet al
doi: 10.1016/j.cmet.2019.10.005 116 WangXZhouSHuXYeCNieQWangKet al
Known for its powerful repair and anti-inflammatory properties, it has been extensively studied for its applications in tissue regeneration, gastrointestinal health, and nervous system protection
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In JANUMET XR-treated patients with a diagnosis or strong suspicion of lactic acidosis, prompt hemodialysis is recommended to correct the acidosis and remove accumulated metformin (metformin is dialyzable, with a clearance of up to 170 mL/min under good hemodynamic conditions)
However, surgery carries greater upfront risks, requires permanent dietary modifications, and involves irreversible anatomical changes