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doi:10.1038/s41591-024-02996-7

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1 , 2 Constipation is reported in 4% to 12% of patients and occurs more frequently in individuals with obesity, likely due to the use of higher doses

Paradoxically, individuals with very high starting BMI may experience greater stone risk due to larger weight loss velocity, making personalized monitoring essential

Consistent with previous reports and our knowledge 19,20 , further analysis showed that many genes involved in BA synthesis and transport were regulated by T3 (Supplementary Fig

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