According to data from the World Health Organization, approximately 225,000 new ovarian cancer cases are reported globally each year, with HGSOC accounting for the vast majority, and its mortality rate ranking among the highest of all gynecological malignancies ( HGSOC is typically diagnosed at an advanced stage, a phenomenon that results in an extremely poor prognosis, as the absence of early diagnosis and effective treatment contributes to a continuous increase in mortality rates ( The clinical manifestations of HGSOC are typically not apparent in the early stages, with patients potentially experiencing non-specific symptoms such as abdominal distension, abdominal pain, decreased appetite, and weight changes, which render early diagnosis particularly challenging
SharmaMDwivediPSingh RawatADwivediAK
Imidazole propionate lessened the immediate glucose-lowering impact of metformin in mice fed a western diet by inhibiting AMPK signaling in the liver via p38-dependent mechanism
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Immune System Guard: Strenuous exercise can temporarily suppress immunity
Untargeted metabolomics Liver samples The collected samples were thawed on ice, and metabolites were extracted using 80% methanol buffer
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