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10.1016/j.cmet.2021.01.015

Feeling cold on retatrutide is most likely due to loss of insulating body fat and reduced caloric intake, both of which lower the body's capacity to generate and retain heat

At the 12 mg dose, nausea was reported by approximately 45% of participants

However, retatrutide delivers superior weight loss results in clinical trials (up to 28.7% vs 15-17% for semaglutide), which means the cost per percentage point of weight loss can be competitive or even favorable