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Metabolic reprogramming mediates hippocampal microglial M1 polarization in response to surgical trauma causing perioperative neurocognitive disorders

In contrast, H3R2 modification (H3R2me1/me2s) by PRMT5 is associated with transcriptional activation [57,58], which activates and recruits WD-40 repeat-containing protein 5 (WDR5) to promote H3K4me3 and gene transcription [59,60]

Its job is to regulate sleep, wake, and eating cycles providing stable energy throughout the day

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