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Peptides with fewer residues are more susceptible to rapid enzymatic degradation, leading to shorter systemic exposure. Fosgerau & Hoffmann, Drug Discovery Today Half-Life Each peptide has a defined biological half-life the time it takes for half of the substance to be eliminated from the bloodstream

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Furthermore, targeted delivery of exendin-4 to the nucleus of the solitary tract (NTS) similarly diminished both operant responding for sucrose under a progressive ratio schedule and conditioned place preference for food rewards in rats (Richard et al., 2015)

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