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Intestinal and brain cells contain prohormone convertase 1 (PC1), which is able to cleave proglucagon into Glicentin, Oxyntomodulin, GLP-1, GLP-2 and IP-2, while pancreatic islet cells contain prohormone convertase 2 (PC2), which capable of cleaving proglucagon into Glucagon and MPGF

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[1] [2] This delayed gastric emptying, alongside effects on central appetite pathways, contributes to their appetite-suppressing effects but also to gastrointestinal side effects

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The glucagon receptor component appears to drive much of this effect

"We can say that it is exposing [people who use peptides] to some potentially serious health risks." Mr Bonenti said consuming retatrutide at a higher dose could have "very significant" consequences