If uneven skin tone or dark spots are affecting your confidence, youve likely come across Glutathione
It has low bioavailability because the tripeptide is the substrate of proteases (peptidases) of the alimentary canal, and due to the absence of a specific carrier of glutathione at the level of the cell membrane
No single cycling protocol has proven superior
Human and animal blood also contain relatively high levels of glutathione, while its content in plant tissues is generally lower
Cysteine residues in Keap1 act as sensors for electrophiles and oxidants, and their oxidation leads to the release and subsequent translocation of Nrf2 into the nucleus where it can bind to the ARE4 sequence in the promoter region of genes involved in antioxidant defense (Moinova and Mulcahy 1999)
What exists is a genuine, reproducible anti-inflammatory and antioxidant mechanism, and a reasonable inference that it's relevant to a condition partly driven by those same pathways