FDA-Labeled Indications for Chronic Weight Management As of early 2026, two medications carry FDA indications specifically for chronic weight management in adults: Wegovy (semaglutide 2.4 mg) approved 2021 Zepbound (tirzepatide) approved 2023 Liraglutide (Saxenda) is also approved for weight management but has been largely supplanted by the once-weekly options
GLP-1 medications fall neatly into the four pillars of obesity care management, Alexander and Basilico both said
As such, effective management of obesity requires a personalized, multidisciplinary approach combining behavioral and dietary interventions, pharmacological therapies, physical activity, and surgery
Common side effects include nausea, diarrhea, and constipation usually subsiding over time
Some evidence suggests dual agonists might better preserve lean body mass during weight loss, though this remains under investigation
It is whether we can lose the right weight