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Similar content being viewed by others Introduction Brain disorders, such as brain tumors, multiple sclerosis, strokes, traumatic brain injuries and neurodegenerative diseases like Parkinsons disease (PK) and Alzheimers disease (AD), pose great health challenges

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We confirm that co-treatment with 5FU and mitochondrial inhibitors, particularly CI inhibitors IACS-010759 (a specific CI inhibitor under clinical evaluation 51 ) and metformin hydrochloride (a treatment for diabetes that inhibits CI 52 ), increases growth arrest and death in CRC cells (Fig