Gastrointestinal burning and acid reflux : Patients may experience chronic heartburn, gastrointestinal burning in the chest or throat, and esophageal damage from prolonged acid reflux
Published in the European Journal of Nutrition, this study evaluated the effects of daily oral Setria glutathione (250 mg or 1,000 mg/day) on 54 healthy adults
R 11 is H, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 6 cycloalkyl, C 2 -C 7 heterocycloalkyl, C 6 -C 10 aryl, C 3 -C 9 heteroaryl, C 1 -C 6 alkylC 3 -C 6 cycloalkyl, C 1 -C 6 alkylC 6 -C m aryl, or C 1 -C 6 alkylC 3 -C 9 heteroaryl
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This dose selection was informed by the Phase 2 observation that the 36 mg and 45 mg doses showed only modestly different efficacy but the 45 mg dose carried higher rates of gastrointestinal adverse events
PMID 7596706
