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It has been suggested that riboflavin therapy increases miR-203 expression, which inhibits c-Jun expression, thus increasing neuronal survival ( Riboflavin Ameliorates Mitochondrial Dysfunction Case reports of mitochondrial diseases have emphasized the beneficial effects of riboflavin administration

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You absolutely must not use non-sterile water

However, consider spacing them out for optimal absorption

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10.1089/ars.2009.2601 Antioxid Redox