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On legality: it was never FDA approved, partly because its lethal dose is unknown

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[2] The six binding proteins and their distinct roles The IGFBP family is not a single carrier but six related proteins with overlapping yet distinct functions, and appreciating their diversity clarifies exactly what IGF-1 LR3 was engineered to escape: IGFBP-1 is acutely regulated by insulin and nutritional state

Journal of Inherited Metabolic Disease

Ipamorelin is less appetite-driving than GHRP-6