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Safety signals identified through extended follow-up include: Gastrointestinal effects : Nausea, vomiting, and diarrhea remain the most common adverse events, typically diminishing over time but causing discontinuation in approximately 57% of patients Gallbladder disease : Increased incidence of cholelithiasis and cholecystitis, possibly associated with weight loss, though the exact mechanism remains under investigation Diabetic retinopathy : Risk of complications, particularly with rapid glycemic improvement in patients with pre-existing retinopathy Acute kidney injury : Risk associated with severe gastrointestinal adverse events leading to dehydration Pancreatitis : Rare cases reported, though causality remains uncertain
Cell Stem Cell 7 , 7889 (2010)
2023 , 2 147+ , 24/7,
MCAS is a condition where mast cells inappropriately release inflammatory mediators, and it can present with a wide and confusing array of symptoms including anxiety, heart palpitations, headaches, hives, flushing, skin rashes, GI issues, and more
Peptides are being studied for their potential role in regenerative medicine