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Finding each patient's optimal dose requires systematic approach beginning with conservative starting doses and methodical titration based on response

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Receptor Dynamics and Sensitivity Prolonged exposure to any signaling molecule raises questions about receptor desensitization

Nat Immunol (2010) 11(5):4118.10.1038/ni.1857 121 DengJLuPDZhangYScheunerDKaufmanRJSonenbergNet alTranslational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2